Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS)
Identifieur interne : 007D04 ( Main/Exploration ); précédent : 007D03; suivant : 007D05Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS)
Auteurs : F. Castro-Giner [Espagne] ; R. De Cid [Espagne] ; J R Gonzalez [Espagne] ; D. Jarvis [Royaume-Uni] ; J. Heinrich [Allemagne] ; C. Janson [Suède] ; E R Omenaas [Norvège] ; M C Matheson [Australie] ; I. Pin [France] ; J M Ant [Espagne] ; M. Wjst [Allemagne] ; X. Estivill [Espagne] ; M. Kogevinas [Espagne, Grèce, Canada]Source :
- Thorax [ 0040-6376 ] ; 2010-02.
Descripteurs français
- Wicri :
- topic : Allergie.
English descriptors
- KwdEn :
- Allergy, Asthma, Asthma susceptibility gene, Atopic, Atopic asthma, Atopy, Barcelona, Body mass index, Bonferroni, Bonferroni correction, Candidate genes, Chromosome, Clin, Cohort, Comparison group, Ecrhs, European community, Gene, Genet, Gure, Haplotype, Health survey, High serum, Locus, Npsr1, Npsr1 gene, Npsr1 polymorphisms, Npsr1 snps, Odds ratios, Online, Online supplement, Onset asthma, Other studies, Persistent asthma, Phenotype, Polymorphism, Positional, Receptor, Respir, Respir crit care, Single nucleotide polymorphisms, Smoking status, Snp, Susceptibility, Thorax.
- Teeft :
- Allergy, Asthma, Asthma susceptibility gene, Atopic, Atopic asthma, Atopy, Barcelona, Body mass index, Bonferroni, Bonferroni correction, Candidate genes, Chromosome, Clin, Cohort, Comparison group, Ecrhs, European community, Gene, Genet, Gure, Haplotype, Health survey, High serum, Locus, Npsr1, Npsr1 gene, Npsr1 polymorphisms, Npsr1 snps, Odds ratios, Online, Online supplement, Onset asthma, Other studies, Persistent asthma, Phenotype, Polymorphism, Positional, Receptor, Respir, Respir crit care, Single nucleotide polymorphisms, Smoking status, Snp, Susceptibility, Thorax.
Abstract
Background Several genes identified by positional cloning have been associated with asthma and atopy, but few findings have been replicated. Age at onset of asthma has been associated with different phenotypic characteristics, and with variants at chromosome 17q21 identified through genome-wide association. This study examined the associations and age-specific effects on asthma, atopy and bronchial hyper-responsiveness (BHR) of five candidate genes previously identified by positional cloning (ADAM33, PHF11, NPSR1, DPP10, SPINK5). Methods 51 polymorphisms from 2474 participants from 13 countries who took part in the European Community Respiratory Health Survey (1990–2000) were studied. Asthma and age at onset of asthma were assessed by questionnaire data, BHR by methacholine challenge and atopy by specific immunoglobulin E to four common allergens. Results Significant associations with asthma, atopy and particularly for asthma with atopy were observed for a large region of 47 kb in the NPSR1 gene, even after Bonferroni correction for multiple comparisons (p<0.001). The associations with NPSR1 were stronger in those reporting a first attack of asthma before the age of 15, with statistically significant interactions with age of onset found for three SNPs. The evidence for ADAM33 and BHR and for an age-specific effect of two SNPs in DPP10 and asthma was weaker. Conclusion This study provides further evidence for an effect of NPSR1 on asthma, atopy and atopic asthma. In addition, this analysis suggests a role for NPSR1 in early-onset asthma driven by the strong effect of this gene on atopic asthma.
Url:
DOI: 10.1136/thx.2009.119628
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Grèce, Norvège, Royaume-Uni, Suède
- Angleterre, Attique (région), Auvergne-Rhône-Alpes, Bavière, Catalogne, District de Haute-Bavière, East Middle Sweden, Grand Londres, Rhône-Alpes, Svealand, Victoria (État)
- Athènes, Barcelone, Grenoble, Londres, Melbourne, Munich, Uppsala
- Université d'Uppsala, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001417
- to stream Istex, to step Curation: 001417
- to stream Istex, to step Checkpoint: 000D28
- to stream Main, to step Merge: 008398
- to stream Main, to step Curation: 007D04
Le document en format XML
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Janson</name><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Omenaas, E R" sort="Omenaas, E R" uniqKey="Omenaas E" first="E R" last="Omenaas">E R Omenaas</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Medicine, University of Bergen, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Centre for Clinical Research, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Matheson, M C" sort="Matheson, M C" uniqKey="Matheson M" first="M C" last="Matheson">M C Matheson</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Pin, I" sort="Pin, I" uniqKey="Pin I" first="I" last="Pin">I. Pin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U823, Centre de Recherche Albert Bonniot, Immunobiologie et Immunothérapie des cancers, La Tronche</wicri:regionArea><wicri:noRegion>La Tronche</wicri:noRegion><wicri:noRegion>La Tronche</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Health and Experimental Sciences, University Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Wjst, M" sort="Wjst, M" uniqKey="Wjst M" first="M" last="Wjst">M. Wjst</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Helmholtz Centre GSF, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Estivill, X" sort="Estivill, X" uniqKey="Estivill X" first="X" last="Estivill">X. Estivill</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Genes and Disease Program, Center for Genomic Regulation, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Health and Experimental Sciences, University Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>National School of Public Health, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Thorax</title><title level="j" type="abbrev">Thorax</title><idno type="ISSN">0040-6376</idno><idno type="eISSN">1468-3296</idno><imprint><publisher>BMJ Publishing Group Ltd and British Thoracic Society</publisher><date type="published" when="2010-02">2010-02</date><biblScope unit="volume">65</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="124">124</biblScope></imprint><idno type="ISSN">0040-6376</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0040-6376</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allergy</term><term>Asthma</term><term>Asthma susceptibility gene</term><term>Atopic</term><term>Atopic asthma</term><term>Atopy</term><term>Barcelona</term><term>Body mass index</term><term>Bonferroni</term><term>Bonferroni correction</term><term>Candidate genes</term><term>Chromosome</term><term>Clin</term><term>Cohort</term><term>Comparison group</term><term>Ecrhs</term><term>European community</term><term>Gene</term><term>Genet</term><term>Gure</term><term>Haplotype</term><term>Health survey</term><term>High serum</term><term>Locus</term><term>Npsr1</term><term>Npsr1 gene</term><term>Npsr1 polymorphisms</term><term>Npsr1 snps</term><term>Odds ratios</term><term>Online</term><term>Online supplement</term><term>Onset asthma</term><term>Other studies</term><term>Persistent asthma</term><term>Phenotype</term><term>Polymorphism</term><term>Positional</term><term>Receptor</term><term>Respir</term><term>Respir crit care</term><term>Single nucleotide polymorphisms</term><term>Smoking status</term><term>Snp</term><term>Susceptibility</term><term>Thorax</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Allergy</term><term>Asthma</term><term>Asthma susceptibility gene</term><term>Atopic</term><term>Atopic asthma</term><term>Atopy</term><term>Barcelona</term><term>Body mass index</term><term>Bonferroni</term><term>Bonferroni correction</term><term>Candidate genes</term><term>Chromosome</term><term>Clin</term><term>Cohort</term><term>Comparison group</term><term>Ecrhs</term><term>European community</term><term>Gene</term><term>Genet</term><term>Gure</term><term>Haplotype</term><term>Health survey</term><term>High serum</term><term>Locus</term><term>Npsr1</term><term>Npsr1 gene</term><term>Npsr1 polymorphisms</term><term>Npsr1 snps</term><term>Odds ratios</term><term>Online</term><term>Online supplement</term><term>Onset asthma</term><term>Other studies</term><term>Persistent asthma</term><term>Phenotype</term><term>Polymorphism</term><term>Positional</term><term>Receptor</term><term>Respir</term><term>Respir crit care</term><term>Single nucleotide polymorphisms</term><term>Smoking status</term><term>Snp</term><term>Susceptibility</term><term>Thorax</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Allergie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Several genes identified by positional cloning have been associated with asthma and atopy, but few findings have been replicated. Age at onset of asthma has been associated with different phenotypic characteristics, and with variants at chromosome 17q21 identified through genome-wide association. This study examined the associations and age-specific effects on asthma, atopy and bronchial hyper-responsiveness (BHR) of five candidate genes previously identified by positional cloning (ADAM33, PHF11, NPSR1, DPP10, SPINK5). Methods 51 polymorphisms from 2474 participants from 13 countries who took part in the European Community Respiratory Health Survey (1990–2000) were studied. Asthma and age at onset of asthma were assessed by questionnaire data, BHR by methacholine challenge and atopy by specific immunoglobulin E to four common allergens. Results Significant associations with asthma, atopy and particularly for asthma with atopy were observed for a large region of 47 kb in the NPSR1 gene, even after Bonferroni correction for multiple comparisons (p<0.001). The associations with NPSR1 were stronger in those reporting a first attack of asthma before the age of 15, with statistically significant interactions with age of onset found for three SNPs. The evidence for ADAM33 and BHR and for an age-specific effect of two SNPs in DPP10 and asthma was weaker. Conclusion This study provides further evidence for an effect of NPSR1 on asthma, atopy and atopic asthma. In addition, this analysis suggests a role for NPSR1 in early-onset asthma driven by the strong effect of this gene on atopic asthma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Norvège</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Bavière</li><li>Catalogne</li><li>District de Haute-Bavière</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Rhône-Alpes</li><li>Svealand</li><li>Victoria (État)</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Grenoble</li><li>Londres</li><li>Melbourne</li><li>Munich</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li><li>Université de Melbourne</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Castro Giner, F" sort="Castro Giner, F" uniqKey="Castro Giner F" first="F" last="Castro-Giner">F. Castro-Giner</name></region><name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name><name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name><name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name><name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name><name sortKey="Castro Giner, F" sort="Castro Giner, F" uniqKey="Castro Giner F" first="F" last="Castro-Giner">F. Castro-Giner</name><name sortKey="Castro Giner, F" sort="Castro Giner, F" uniqKey="Castro Giner F" first="F" last="Castro-Giner">F. Castro-Giner</name><name sortKey="De Cid, R" sort="De Cid, R" uniqKey="De Cid R" first="R" last="De Cid">R. De Cid</name><name sortKey="De Cid, R" sort="De Cid, R" uniqKey="De Cid R" first="R" last="De Cid">R. De Cid</name><name sortKey="Estivill, X" sort="Estivill, X" uniqKey="Estivill X" first="X" last="Estivill">X. Estivill</name><name sortKey="Estivill, X" sort="Estivill, X" uniqKey="Estivill X" first="X" last="Estivill">X. Estivill</name><name sortKey="Estivill, X" sort="Estivill, X" uniqKey="Estivill X" first="X" last="Estivill">X. Estivill</name><name sortKey="Gonzalez, J R" sort="Gonzalez, J R" uniqKey="Gonzalez J" first="J R" last="Gonzalez">J R Gonzalez</name><name sortKey="Gonzalez, J R" sort="Gonzalez, J R" uniqKey="Gonzalez J" first="J R" last="Gonzalez">J R Gonzalez</name><name sortKey="Gonzalez, J R" sort="Gonzalez, J R" uniqKey="Gonzalez J" first="J R" last="Gonzalez">J R Gonzalez</name><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jarvis, D" sort="Jarvis, D" uniqKey="Jarvis D" first="D" last="Jarvis">D. Jarvis</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Heinrich, J" sort="Heinrich, J" uniqKey="Heinrich J" first="J" last="Heinrich">J. Heinrich</name></region><name sortKey="Wjst, M" sort="Wjst, M" uniqKey="Wjst M" first="M" last="Wjst">M. Wjst</name></country><country name="Suède"><region name="Svealand"><name sortKey="Janson, C" sort="Janson, C" uniqKey="Janson C" first="C" last="Janson">C. Janson</name></region></country><country name="Norvège"><noRegion><name sortKey="Omenaas, E R" sort="Omenaas, E R" uniqKey="Omenaas E" first="E R" last="Omenaas">E R Omenaas</name></noRegion><name sortKey="Omenaas, E R" sort="Omenaas, E R" uniqKey="Omenaas E" first="E R" last="Omenaas">E R Omenaas</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Matheson, M C" sort="Matheson, M C" uniqKey="Matheson M" first="M C" last="Matheson">M C Matheson</name></region></country><country name="France"><noRegion><name sortKey="Pin, I" sort="Pin, I" uniqKey="Pin I" first="I" last="Pin">I. Pin</name></noRegion><name sortKey="Pin, I" sort="Pin, I" uniqKey="Pin I" first="I" last="Pin">I. Pin</name><name sortKey="Pin, I" sort="Pin, I" uniqKey="Pin I" first="I" last="Pin">I. Pin</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name></region></country><country name="Canada"><noRegion><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M" last="Kogevinas">M. Kogevinas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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